An immune cell weaponized with a synthetic receptor (CAR-T) which combines tumor specific targeting capability with T-cell activation to seek out and eradicate cancer.
Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance.
Boyiadzis MM, Dhodapkar MV, Brentjens RJ, Kochenderfer JN, Neelapu SS, Maus MV, Porter DL, Maloney DG, Grupp SA, Mackall CL, June CH, Bishop MR.
J Immunother Cancer.
2018 Dec 4;6(1):137. PMID: 30514386
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