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T Cell Receptor

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  • T Cell Receptor

An immune cell weaponized with a T Cell Receptor (TCR) enables targeting of intracellular proteins presented on the tumor cell leading to recognition by the immune cell and eradication of cancer cells


References

  • T-cell receptor-engineered T cells for cancer treatment: current status and future directions.
    Ping Y, Liu C, Zhang Y.
    Protein Cell.
    2018 Mar;9(3):254-266. PMID: 28108950
    Free PMC Article

  • T cell receptor-engineered T cells for leukemia immunotherapy.
    Zhang Y, Li Y.
    Cancer Cell Int.
    2019 Jan 3;19:2. PMID: 30622438
    Free PMC Article

  • The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review.
    Zhang J, Wang L.
    Technol Cancer Res Treat.
    2019 Jan 1;18:1533033819831068. PMID: 30798772
    Free PMC Article

  • Adoptive T Cell Therapy: New Avenues Leading to Safe Targets and Powerful Allies.
    Hammerl D, Rieder D, Martens JWM, Trajanoski Z, Debets R.
    Trends Immunol.
    2018 Nov;39(11):921-936. PMID: 30309702

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