T Cell Receptor

An immune cell weaponized with a T Cell Receptor (TCR) enables targeting of intracellular proteins presented on the tumor cell leading to recognition by the immune cell and eradication of cancer cells

References

T-cell receptor-engineered T cells for cancer treatment: current status and future directions.
Ping Y, Liu C, Zhang Y.
Protein Cell.
2018 Mar;9(3):254-266. PMID: 28108950
Free PMC Article
T cell receptor-engineered T cells for leukemia immunotherapy.
Zhang Y, Li Y.
Cancer Cell Int.
2019 Jan 3;19:2. PMID: 30622438
Free PMC Article
The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review.
Zhang J, Wang L.
Technol Cancer Res Treat.
2019 Jan 1;18:1533033819831068. PMID: 30798772
Free PMC Article
Adoptive T Cell Therapy: New Avenues Leading to Safe Targets and Powerful Allies.
Hammerl D, Rieder D, Martens JWM, Trajanoski Z, Debets R.
Trends Immunol.
2018 Nov;39(11):921-936. PMID: 30309702